MIAMI, FLORIDA (EMBARGOED UNTIL MAY 25, 2023, AT 5 P.M. ET) – An early-phase study led by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine ...
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Small molecule inhibitors restore normal BRAF structure, offering insight into cancer-causing mutations
An altered structure that 'mimics' the active form of BRAF Around half of all cancers are associated with dysfunction of the MAPK pathway, a communication system that enables cells to integrate ...
The association of alternate VEGF ligands with resistance to anti-VEGF therapy in metastatic colorectal cancer. This is an ASCO Meeting Abstract from the 2011 ASCO Annual Meeting I. This abstract does ...
BRAF is the most commonly mutated gene associated with melanoma, found in more than 50 percent of patients. The gene encodes a cytoplasmic kinase that is a member of the MAPK signal-transduction ...
Biomedical engineers have demonstrated that one of the most dangerous mutations found in skin cancers might moonlight as a pathway to mending a broken heart. The genetic mutation in the protein BRAF, ...
New research overseen by University of Colorado Cancer Center member Rebecca Schweppe, PhD, could lead to improved treatment for people with thyroid cancer characterized by a mutation in the BRAF gene ...
The role of BRAF in adult malignancy has been well documented over the last decade and recent data have extended these findings to a number of pediatric cancers. In this and the accompanying articles, ...
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