Stem cells have great applications in regenerative medicine. While transcription factors traditionally dominate fate determination research, recent 3D genomics reveals chromatin topology’s critical ...
Memorial Sloan Kettering Cancer Center researchers have identified a metabolic switch that determines whether intestinal stem cells become absorptive or secretory cells. Manipulating the enzyme OGDH ...
Researchers from Kyushu University have developed an innovative computational method, called ddHodge, that can reconstruct the complex dynamics of how cells decide their fate. As reported in Nature ...
Human cells decode dynamics Wnt signals using an anti-resonant filter that suppresses intermediate-frequency inputs and is capable of redirecting developmental fate outcomes, including germ-layer ...
Plant stem cells are crucial for the world's food supply, animal feed, and fuel production. They lay the foundation for how plants grow. Yet, much about these mysterious building blocks remains ...
The diagram depicts negative feedback mechanisms via IκB proteins and A20 in the canonical pathway, and IKKα onto NIK in the non-canonical pathway. There are cross-talk mechanisms such as NIK ...
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