Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During ...

Researchers have revealed the structural mechanisms of a major DNA repair pathway in human cells. The research, published today as a Reviewed Preprint in eLife, is described by the editors as a ...

An elegant collaboration between researchers in the UK's two core-funded Medical Research Council Research Institutes, the Laboratory of Medical Sciences (LMS) in London and the Laboratory of ...

A new study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most powerful genetic "on switches" in cancer cells, called super-enhancers, drive ...

Researchers have uncovered answers that provide the detail to explain two specific DNA repair processes that have long been in question. Researchers from the University of Birmingham have uncovered ...

A research team has successfully identified a novel DNA damage repair pathway in human cells. This study is the first to discover that proteins present in the nuclear membrane of cells directly ...

Insights could not only pave the way for new treatment strategies for genetic disorders, cancer and neurodegenerative diseases, but also enhance gene-editing technologies.

DNA can sustain serious injuries called double strand breaks, in which both strands of the helix snap. These breaks are among the most dangerous forms of DNA damage and immediately trigger the cell's ...

Objectives Understanding the molecular changes in the preclinical synovium is crucial for identifying factors that drive ...