Researchers have identified a specific hormone produced by pancreatic beta cells as a direct driver of obesity-linked pancreatic cancer in mouse models, shifting scientific attention away from insulin ...

Researchers show that obesity alters pancreatic cells to produce cholecystokinin, which drives cancer growth, revealing new links between hormone signaling, cellular stress, and tumor risk.

T cell activation—the process by which these key immune defenders recognize threats and mobilize against them—depends on exquisitely timed molecular signals. Now researchers have captured one of the ...

Organoids—tiny, lab-grown 3D clusters of cells—are a useful tool for studying organ development, disease, and drug responses. These miniature organs-in-a-dish are powerful, but they’re not perfect: ...

Hormones coordinate different body functions by carrying messages through the bloodstream to target cells and tissues. Hormonal imbalances occur through inadequate or excess hormone synthesis, which ...

WEST LAFAYETTE, Ind. — In the march of metastasis, a molecular trail of crumbs guides some cancer cells from the primary tumor to establish new colonies within the body. Blocking the cells’ ability to ...

In some cases, HR-positive/HER2-negative breast cancers may over time become resistant to endocrine therapy. This can occur through mutations in the estrogen receptor ...

Researchers have uncovered a surprising molecular chain reaction in the brain that may play a role in some forms of autism. The study suggests that nitric oxide, a tiny signaling molecule normally ...

Cells use various signaling molecules to regulate the nervous, immune, and vascular systems. Among these, nitric oxide (NO) and ammonia (NH₃) play important roles, but their chemical instability and ...