Faulty lipid regulation in CLL patients impairs T-cell function, affecting treatment outcomes and resistance to current therapies. Differences in lipid metabolism between CLL patients and healthy ...

The raw material for de novo fatty acid synthesis is acetyl-CoA, which can be obtained via the citrate shuttle pathway or from acetic acid. ACC and FASN catalyze the conversion of acetyl-CoA into ...

DDAH1 plays a critical role in hepatic lipid metabolism under fasting conditions by modulating FABP1 expression and AMPK/mTOR-mediated autophagy. The liver plays a central role in maintaining systemic ...

Lipid metabolism has emerged as a central player in the progression and therapy resistance of breast cancer, particularly the aggressive subtype known as triple-negative breast cancer (TNBC). This ...

Mutations in the lipid transporter ABCA7 are known to elevate the risk of Alzheimer’s disease, but how they do so has been murky. Now, scientists led by Li-Huei Tsai at MIT in Cambridge, Massachusetts ...

Not all proteins function the same way in the body, especially when it comes to heart health. In a review of controlled ...