BAE: Bovine aortic endothelial; RHP: Recombinant human protein. NSAIDs variably inhibit prostaglandin H synthase (COX). COX-2 was cloned in 1991, and it was subsequently established that COX-1 does ...
The discovery of cyclooxygenase (COX) isoforms, COX-1 and COX-2, in the early 1990s helped explain how non-steroidal anti-inflammatory drugs (NSAIDs) work and led to specific agents with fewer ...
Antman notes that despite initial claims of greater GI safety for this class of NSAID, COX-2 is in fact needed for GI mucosal protection; used alone, a COX-2 inhibitor can damage the mucosa, and the ...
CONCORD, Mass.--(BUSINESS WIRE)--Tremeau Pharmaceuticals today announced that it will host a key opinion leader (KOL) webinar to discuss the unmet medical need in migraine management and the potential ...
Non-steroidal anti-inflammatory drugs (NSAIDs) and steroids (see Corticosteroid Therapy) can be useful for acute pain relief in patients with rheumatoid arthritis (RA). In osteoarthritis, studies have ...
NEW YORK (Reuters Health) - Although all of the common strategies protect the upper gastrointestinal tract from the complications of nonsteroidal anti-inflammatory drugs (NSAIDs), popular ...
Aspirin was introduced into clinical medicine in 1899 and its anti-inflammatory, analgesic and antipyretic properties were accompanied by the onset of gastrointestinal and renal toxicity. Over the ...
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