In recent years, CryoEM has enabled scientists to decipher the structures of the fibrils that form various deposits in neurodegenerative disease. They have not only solved disease-specific folding ...
Amyloid fibrils appear in many neurodegenerative diseases, and scientists are eager to understand how they form and spread. But amyloids—clumped aggregations of misfolded proteins—can be difficult to ...
Research led by the University of Michigan has provided compelling evidence that could solve a fundamental mystery in the makeup of fibrils that play a role in Alzheimer's, Parkinson's and other ...
Research led by the University of Michigan has shown that the molecular polyphosphate, shown in red, could be what's been called the "mystery density" inside fibrils—like the one shown in ...
Research led by the University of Michigan has provided compelling evidence that could solve a fundamental mystery in the makeup of fibrils that play a role in Alzheimer’s, Parkinson’s and other ...
Inorganic polyphosphate (polyP) is a ubiquitous, evolutionarily conserved polymer composed of linear chains of inorganic phosphate residues. Long recognised as an energy metabolite and phosphate ...
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