A holistic inquiry into how toxic tau impacts synapses provides a new take on the processes that lead to neuronal dysfunction ...

A study maps how toxic tau disrupts synapses over time, showing early postsynaptic damage that later spreads presynaptically.

A research group led by Specially appointed professor, Dr. Tatsuo Suzuki of Shinshu University School of Medicine developed a new purification protocol for Postsynaptic density (PSD) lattice, a core ...

Dynamic changes in the structural characteristics of the postsynaptic membrane and, in particular, of dendritic spines have been a topic of great interest over the last decade (reviewed in refs. 1–7).

This original animation illustrates that presynaptic neurons secrete VLK, which then phosphorylates the extracellular side of ephrin type-B receptor 2 (EphB2) extruding from the membranes of ...

A research team revealed in an animal study a previously unknown role of a presynaptic adhesion molecule to tell the new change by regulating postsynaptic NMDA-type receptor responses at excitatory ...

Precise synaptogenesis is crucial to brain development, and depends on the ability of specific partner cells to locate and communicate with one another. Dynamic properties of axonal filopodia during ...

A protein that appears in postsynaptic protein agglomerations has been found to be crucial to their formation. The Kobe University discovery identifies a new key player for synaptic function and sheds ...

Postsynaptic Simulator transforms principles about neuronal activation into a fun game. The app is divided into eight different levels, each of which describes a different objective to the user. Each ...

Synaptic plasticity describes the biological process that enables learning and memory through facilitating changes in the connections between synapses. Interaction with the external world results in ...