PTIR calculates the rates at which originally monomeric proteins are transformed into aggregates at various temperatures under initial-rate settings. Utilizing SMSLS for identical conditions generates ...

Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail.

A team of researchers at Kumamoto University has uncovered a groundbreaking mechanism in the formation of harmful protein aggregates that lead to neurodegenerative diseases such as Parkinson's Disease ...

Protein aggregation is typical of various neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases such as Creutzfeld-Jakob disease. A research team has now used new in vitro and ...

Raghu R. Chivukula, MD, Ph.D., a physician-investigator in the Departments of Medicine & Surgery and the Center for Genomic Medicine at Massachusetts General Hospital and Harvard Medical School, is ...

Yeast prions are increasingly recognised as pivotal agents in non-Mendelian inheritance, whereby protein conformations rather than nucleic acids dictate heritable traits. In Saccharomyces cerevisiae ...

Researchers have used computational models to understand what drives the accumulation of alpha-synuclein protein, a key culprit in the development of Parkinson’s disease. The study, published today as ...

Protein stabilization is key to tackling protein aggregation, which is involved in neurodegenerative diseases. Rajan et al. explore molecular mechanisms by which zwitterionic polymers stabilize ...

Scientists have identified a critical breakdown in the cellular machinery that produces proteins in aging brains.

Researchers at the University of Cologne’s CECAD Cluster of Excellence for Aging Research and the CEPLAS Cluster of Excellence for Plant Sciences have discovered a promising synthetic plant ...

Loss and dysfunction of synapses have been linked to age-related cognitive decline and observed in Alzheimer's and other neurodegenerative diseases, although a cascade of events likely leads to those ...