A new study reveals that age-related changes in the gut microbiota directly impair intestinal stem cell (ISC) function and that restoring a youthful microbial environment can reverse this decline.

UCSF scientists engineered old fibroblast cells to turn their genes on and off in the same way as young fibroblasts. The old ...

Researchers have identified OTULIN, an immune-regulating enzyme, as a key trigger of tau buildup in the brain. When OTULIN ...

Life runs on information. In living systems, that information takes two main forms: the genome and the epigenome. The genome stays mostly stable. The epigenome, however, constantly shifts, shaped by ...

Aging-focused biotech companies share how they're advancing therapies to slow disease, extend lifespan, and transform medicine.

The researchers have found that the increased expression of transcription factor DMTF1 can improve neural stem cell function, ...

Scientists at Stanford Medicine have discovered a treatment that can reverse cartilage loss in aging joints and even prevent arthritis after knee injuries. By blocking a protein linked to aging, the ...

New multi-omic data reveal that GLP-1 signaling in the brain can drive body-wide rejuvenation, offering a potential weight-neutral path to preserving strength and organ resilience with age. Study: ...

Taken together, the work shows that spaceflight can speed and then reverse blood-based aging signals through immune and ...