Lipids act as extracellular and intracellular messengers to control cell fate in normal physiology and disease. When deregulated, lipid signalling contributes to inflammation and cancer, metabolic, ...

The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P), formed by activation of sphingosine kinase in response to diverse stimuli, is an important lipid mediator that has novel dual ...

Capsaicin, a novel radiosensitizer, acts via a TRPV6 mediated phenomenon. Background: Hypoxia promotes neovascularization, metastasis, growth and resistance to treatments. The activation of HIF-1α has ...

: (A) Representative images of S1pr3 immunofluorescence staining (upper panel, scale bar = 50 μm), HE staining (middle panel, scale bar = 100 μm), and Masson's trichrome staining (lower panel, scale ...

In a recent study posted to the bioRxiv* preprint server, researchers explored sphingosine kinases (SK) inhibitors and characterized the role of SKs in Ebola virus (EBOV) entry. Study: Sphingosine ...

Sphingolipids are important biological molecules, a class of lipids that have a backbone of sphingoid bases including sphingosine (aliphatic amino alcohol) or another structurally similar compound. In ...

Analytical validation of the Oncomine Immune Response Research Assay (OIRRA) in a CLIA and CAP regulated laboratory for formalin fixed, paraffin embedded (FFPE) solid tumor specimens. Effect of the ...

Measuring circulating blood levels of a specific lipid, sphingosine, allows clinicians to predict whether COVID-19-positive patients will go on to develop symptoms or remain asymptomatic. Researchers ...

Sphingosine is a membrane component in all cells and constitutes 25% of the lipid in the myelin sheath. Sphingosine is phosphorylated by ubiquitously expressed sphingosine kinases. S1P regulates cell ...

New research presented at the 41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS 2025) demonstrates that ocrelizumab provides superior control of ...