The underlying mechanism is well known: put simply, synaptic signal transmission is triggered when calcium ions in the sender neuron bind to specific sensor proteins, which causes messengers—known as ...

Low-dose ephedrine disrupts synaptic signaling and behavior in adult zebrafish. Schematic overview of the experimental design, key neurotoxic mechanisms, and functional outcomes following chronic ...

In a rat model of chronic heart failure, Xijiaqi Formula improved cardiac indices and rescued learning/memory deficits while ...

Astrocytes use the MEGF10 receptor to prune synapses in the striatum, a process essential for dopamine-driven motor learning.

One of society’s greatest medical challenges is to understand and develop effective treatments for disorders of intellectual disability (ID). Around 2–3 percent of the global population meet the ...

The screen worked, flagging expected cancer genes. But it also kept returning something that seemed impossible: genes for synapses, glutamate receptors, and neural signaling pathways. “We absolutely ...

Neurodegenerative disease profoundly affects structures and pathways responsible for memory, cognition, and higher-order ...

Transcriptomic analyses revealed thousands of differentially expressed genes in the brain, with synaptogenesis signaling emerging as the most significantly disrupted pathway—even at the lowest ...