The study, published in Genomic Psychiatry, identified how stress hormones activate specific RNA molecules called long ...
Changes in histone modifications of genes involved in flowering. (a) The removal of Polycomb complexes by SDG7 protein. (b) Transcription elongation and the deposition of H3K36me3 by SDG8 protein. PRE ...
Abstract HighlightsORIC-944 is a potent, highly selective, orally bioavailable, allosteric inhibitor of PRC2 that demonstrates best-in-class drug properties, including potency, solubility, and ...
Scientists have discovered how mutations in a specific gene drive the rare developmental disorder Weaver syndrome, which is marked by intellectual disability and overgrowth and predisposes people with ...
New research led by Professor Yogesh Dwivedi at the University of Alabama at Birmingham uncovers how long noncoding RNAs engage chromatin-silencing machinery under glucocorticoid receptor activation, ...
One of the most fascinating discoveries in biology is that cells have mechanisms for dynamically regulating genetic expression. This ability to promote or restrict the transcription of specific genes ...
ORIC Pharmaceuticals, Inc. announced the presentation of preclinical data on ORIC-944, a selective allosteric inhibitor of PRC2, at the 2025 American Association for Cancer Research Annual Meeting.
Dysregulation of the polycomb repressive complex 2 (PRC2) is associated with epigenetic silencing of tumor suppressor genes, leading to alterations in cell proliferation, differentiation and survival ...
Scientists have discovered how mutations in a specific gene drive the rare developmental disorder Weaver syndrome, which is marked by intellectual disability and overgrowth and predisposes people with ...
Epigenetics, the dynamic regulation of genetic expression, involves complex molecular mechanisms. While the process of gene silencing by methylating the H3K27 position in histones is understood, not ...
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